The Evidence for ALS as a Multisystems Disorder of Limited Phenotypic Expression

Can. J. Neurol. Sci. 2001; 28: 293-308

Figure 3: Microglia activation in ALS assumes two morphological characteristics, including a robust activation and proliferation in the degenerating corticospinal tracts (A; 4x mag.) in which the microglia assume plump, phagocytic morphologies (B; 40x mag.). In the vicinity of degenerating neurons, the microglia are observed in direct opposition to the motor neurons (C; 40x mag.) or surrounding neuroaxonal spheroids (D, 40x mag.). Microglia immunostained with a monoclonal antibody directed to HLA DR with the antigen:antibody conjugate detected using alkaline phosphatase development, yielding a reddish/brown coloration.

 

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