The Evidence for ALS as a Multisystems Disorder of Limited Phenotypic Expression

Can. J. Neurol. Sci. 2001; 28: 293-308

Figure 2: The spectrum of intraneuronal inclusions observed in ALS. By routine silver staining techniques, motor neurons are observed to contain dense, argentophilic material in the form of neuroaxonal spheroids (A; arrow) or a hyalinized cytoplasmic clearing (red arrow) (10x mag.). Using monoclonal antibodies against phosphorylated neurofilaments (SMI 31), dense intracytoplasmic neurofilamentous aggregates (B; 40x mag.) or neuroaxonal spheroids are evident (C, 40x mag.). Both cortical and spinal cord motor neurons are immunoreactive to nitrotyrosine (D, 40x mag). Ubiquinated inclusions within spinal motor neurons can assume a punctate appearance (E, arrow) or a skein-like morphology (E, red arrow) (40x mag.).

 

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