Table 1: Age-associated cognitive decline (AACD) subjects: Neuropsychological test results at initial presentation, compared to published norms. The percentage of AACD subjects scoring at least 1 s.d. below normal for age on each test of cognitive function is also indicated.

Test

No. Subjects
Average +/-S.D.
Range
Normal +/-S.D.
% below 1 S.D.

Education

36
10.8 +/- 3.1
4 to 18

MMSE

36
26.9 +/- 3.0
21 to 30
29.3 +/- 0.9

Boston naming

27
79% +/- 15
43 to 100%
89.5 +/- 13%
30%

Digit Span

34
6.1 +/- 1.2
3.5 to 8
6.4 +/- 1.0
21%

Knopman

36
2.7 +/- 2.2
0 to 7
6.0 +/- 1.8
61%

Logical Memory 1

35
8.1 +/- 3.8
2 to 16
11 +/- 3.0
49%

Logical Memory 2

35
7.5 +/- 5.5
0 to 18
9.6 +/- 3.4
37%

Fluency (F & S)

36
22.5 +/- 8.6
7 to 45
27.8 +/- 7.6
25%

Fluency Animals

36
12.9 +/- 4.1
5 to 23
15.0 +/- 3.2
28%

Digit Symbol

14
31.3 +/- 7.8
15 to 46
43.7 +/- 8.3
7%

Block Design (/51)

16
16.2 +/- 8.4
2 to 29
23.5 +/- 9.9
13%

Visual Perceptual Screen

28
29.7 +/- 0.5
28 to 30
29.8 +/- 0.3
0%

Back to: Lack of Prognostic Significance of SPECT Abnormalities in Non-demented Elderly Subjects with Memory Loss

Table 2: Brain SPECT pattern classification of Holman, Johnson et al.36

SPECT Pattern

Description

A

Normal

B

Bilateral posterior temporal and/or parietal defects

C

Bilateral posterior temporal and/or parietal defects with additional defects

D

Unilateral posterior temporal and/or parietal defects with or without additional defects

E

Frontal defects only

F

Other large defects

G

Multiple small defects

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Table 3: SPECT and selected initial neuropsychological results in AACD subjects. Number of AACD subjects with each SPECT pattern (total n = 36), is shown along with the mean neuropsychological test result within that group of subjects. The overall results for any normal (SPECT pattern A) versus abnormal (SPECT patterns B-G) are also compared.

SPECT Pattern

No. Subjects (%)

MMSE (Av.)

Boston naming (%)

Logical memory I

Fluency (animal)

A

13 (36)

27

68

8.3

11.2

B

4 (11)

28

76

7

12.7

C

1 (3)

28

100

8

12

D

12 (33)

28.3

83

6.8

13.3

E

3 (8)

26.3

90

6.7

14

F

2 (6)

23.5

74

6.5

13

G

1 (3)

30

76.

11

13

B-G

23 (64)

27.6

82.3

7

13.2

.

Back to: Lack of Prognostic Significance of SPECT Abnormalities in Non-demented Elderly Subjects with Memory Loss

Table 4: Follow-up of AACD subjects: initial and follow-up MMSE scores divided according to initial SPECT pattern (n = 34).

SPECT Pattern

No. Subjects (%)

Initial MMSE

F/U MMSE

A

11 (32)

27.1

23.6

B

4 (11)

28

24

C

1 (3)

28

15

D

12 (35)

28.3

25.2

E

3 (9)

26.3

24.3

F

2 (6)

23.5

21

G

1 (3)

30

29

B-G

23 (68)

27.6

23.9

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Table 5: AACD subjects: progression to probable AD according to SPECT pattern (n = 34).

SPECT

No. Subjects

No. Progressing to AD

A

11

6

B

4

2

C

1

1

D

12

5

E

3

2

F

2

2

G

1

0

B-G

23

12

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