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Pathological Laughter Following Intravenous Sodium Valproate

P.C. Jacob and R. Pratap Chand

Abstract: Background: Pathological laughter can be a sign of epilepsy, psychiatric illness, effect of toxins or psychotropic drugs or of structural brain disease. Method: Case Studies. Result: Two patients developed inappropriate uncontrollable laughter following intravenous sodium valproate for treatment of epilepsy. Conclusion: Pathological laughter can be a side effect of intravenous sodium valproate.

Can. J. Neurol. Sci. 1998; 25: 252-253


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