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Symptomatic Dystonias Associated with Structural Brain Lesions: Report of 16 Cases

     Vladimir S Kostic, Marina Stojanovic-Svetel and Aleksandra Kacar

Abstract:   Background: Symptomatic (secondary) dystonias associated isolated lesions in the brain provide insight into etiopathogenesis of the idiopathic form of dystonia and are a basis for establishing the possible correlation between the anatomy of a lesion and the type of dystonia according to muscles affected. Methods: In 358 patients with differently distributed dystonias, a group of 16 patients (4.5%) was encountered in whom dystonia was associated with focal brain lesions. Results: Of the 16 patients, 3 patients had generalized, 3 segmental and 4 hemidystonia, while the remaining 6 patients had focal dystonia. The most frequent etiologies were infarction in 7, and tumor in 4 patients. These lesions were usually found in the lenticular and caudate nucleus, thalamus, and in the case of blepharospasm in the upper brainstem. Conclusions: Our results support the suggestion that dystonia is caused by a dysfunction of the basal ganglia.

Can. J. Neurol. Sci. 1996; 23: 53-56


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