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Pyridoxine Dependent Epilepsy with Iatrogenic Sensory Neuronopathy

     Richard S McLachlan and William F Brown

Abstract:   An 18-year-old man was treated from birth with chronic high dose pyridoxine (vitamin B6) up to 2000 mg per day for pyridoxine-dependent seizures. Within two years of onset of treatment, he developed a sensory neuropathy which did not progress over the following 16 years. Electrophysiological studies were consistent with a pure sensory neuronopathy expressed as centripetal degeneration of processes of the dorsal root ganglion cells.

Can. J. Neurol. Sci. 1995; 22: 50-51

 


 
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